Long-term outcomes of letrozole treatment for precocious puberty in girls with McCune–Albright syndrome
نویسندگان
چکیده
منابع مشابه
Long-term outcomes of letrozole treatment for precocious puberty in girls with McCune-Albright syndrome.
OBJECTIVE McCune-Albright syndrome (MAS) is a rare disorder with a broad spectrum including precocious puberty (PP) due to recurrent estrogen-secreting ovarian cysts. This study evaluates the long-term safety and efficacy of letrozole treatment in large cohort of girls with MAS-associated PP. DESIGN Retrospective cohort analysis. METHODS Clinical data, including history and physical examina...
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Gonadotropin-releasing hormone analogs (GnRHa) are widely used to treat central precocious puberty (CPP). The efficacy and safety of GnRHa treatment are known, but concerns regarding long-term complications are increasing. Follow-up observation results after GnRHa treatment cessation in female CPP patients up to adulthood showed that treatment (especially <6 years) was beneficial for final adul...
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UNLABELLED BACKGROUND McCune-Albright Syndrome (MAS) is usually characterized by the triad of precocious puberty (PP), fibrous dysplasia, and café au lait spots. Previous treatments investigated for PP have included aromatase inhibitors and the estrogen receptor modulator, tamoxifen. Although some agents have been partially effective, the optimal pharmacologic treatment of PP in girls with M...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2016
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje-16-0526